One of my favorite games of the NES era was Mike Tyson's Punch Out.  My cousin and I spent a whole summer trying to beat that game.  The new Punch-Out!! for the Wii is pretty good, but I can't help but feel it's still only a prettier version of a classic game.  On the other side, The Simpsons universe is rife with characters just begging to be in a Punch Out game.  The episode where Homer realizes he can't be knocked out and becomes a boxer is one of my favorites.  I'd love to play a game as Homer instead of Little Mac.  You could meet in the ladies restroom at Moe's, your special move could even be "The Stinga."  Heck, Drederick Taytum is even a blatant rip off of Mike Tyson.  May be even fight Moe a few times as he changes from "Kid Presentable", "Kid Gruesome", and finally "Kid Moe."  The Simpsons wrestling game didn't work out so well, may be boxing would be good?